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من طرف QUSAY ANGEL MARE الخميس يوليو 17, 2008 10:08 amDiseases of the peripheral nerve impact the nerves that control our extremities, our arms and legs. (Read about "Nervous System") The three listed below are all genetically caused.
Charcot-Marie-Tooth Disease (CMT) - CMT is one of the most common inherited disorders, according to MDA. It is estimated to affect between 100,000 and 125,000 people in the United States. NINDS says CMT causes a slow degeneration of the muscles in the foot, lower leg, hand and forearm, and a mild loss of sensation in the limbs, fingers and toes. The first sign of CMT, according to MDA are usually foot problems such as a high arched foot or flexed toes resulting in unusual walking. NINDS says other symptoms of the disorder may include foot bone abnormalities such as high arches and hammer toes, problems with hand function and balance, occasional lower leg and forearm muscle cramping, loss of some normal reflexes, occasional partial sight and/or hearing loss (Read about "Hearing Loss"), and, in some patients, scoliosis. (Read about "Curvature of the Spine") There are two types of the disease. MDA says type 1 usually appears in childhood or the teen years, type 2 later. NINDS says the earlier the symptoms appear, the more severe they are. There is no cure for CMT. Treatment may involve physical therapy (Read about "Rehabilitation"), braces and/or shoe inserts.
Dejerine-Sottas Disease (DS) - DS is sometimes referred to as Type 3 CMT, according to MDA. It is also caused by problems with specific genes. MDA says some of the symptoms include the late development of certain motor skills, including walking, until the child is 3 or 4 years of age. (Read about "Child Development") Other symptoms can include the loss of the ability to walk in later years, hearing and other sensory problems.
Friedreich's Ataxia (FA) - FA is a relatively rare genetic disease that affects about 5,000 people in the United States. MDA says that people of French-Canadian background have a higher rate of the disease. NINDS says FA causes progressive damage to the nervous system affecting balance and coordination. The symptoms include muscle weakness, speech problems and even heart disease. Symptoms usually begin between the ages of 5 and 15 but can appear as early as 18 months or as late as 30 years of age. The first symptom is usually difficulty in walking. The balance and movement problems gradually worsen and slowly spread to the arms and then the trunk. Foot deformities such as clubfoot (Read about "Clubfoot"), flexion (involuntary bending) of the toes, hammer toes, or foot inversion (turning in) may be early signs. Rapid, rhythmic, involuntary movements of the eyeball are common. (Read about "The Eye") Most people with Friedreich's ataxia develop scoliosis (Read about scoliosis in "Curvature of the Spine") which, if severe, may impair breathing. Other symptoms include chest pain, shortness of breath, and heart palpitations. MDA says most FA patients develop heart disease. (Read about "Coronary Heart Disease") There are no known cures.
According to NINDS, currently there is no cure for peripheral nerve diseases. Treatment options focus on symptomatic relief and medications to block pain.
Charcot-Marie-Tooth Disease (CMT) - CMT is one of the most common inherited disorders, according to MDA. It is estimated to affect between 100,000 and 125,000 people in the United States. NINDS says CMT causes a slow degeneration of the muscles in the foot, lower leg, hand and forearm, and a mild loss of sensation in the limbs, fingers and toes. The first sign of CMT, according to MDA are usually foot problems such as a high arched foot or flexed toes resulting in unusual walking. NINDS says other symptoms of the disorder may include foot bone abnormalities such as high arches and hammer toes, problems with hand function and balance, occasional lower leg and forearm muscle cramping, loss of some normal reflexes, occasional partial sight and/or hearing loss (Read about "Hearing Loss"), and, in some patients, scoliosis. (Read about "Curvature of the Spine") There are two types of the disease. MDA says type 1 usually appears in childhood or the teen years, type 2 later. NINDS says the earlier the symptoms appear, the more severe they are. There is no cure for CMT. Treatment may involve physical therapy (Read about "Rehabilitation"), braces and/or shoe inserts.
Dejerine-Sottas Disease (DS) - DS is sometimes referred to as Type 3 CMT, according to MDA. It is also caused by problems with specific genes. MDA says some of the symptoms include the late development of certain motor skills, including walking, until the child is 3 or 4 years of age. (Read about "Child Development") Other symptoms can include the loss of the ability to walk in later years, hearing and other sensory problems.
Friedreich's Ataxia (FA) - FA is a relatively rare genetic disease that affects about 5,000 people in the United States. MDA says that people of French-Canadian background have a higher rate of the disease. NINDS says FA causes progressive damage to the nervous system affecting balance and coordination. The symptoms include muscle weakness, speech problems and even heart disease. Symptoms usually begin between the ages of 5 and 15 but can appear as early as 18 months or as late as 30 years of age. The first symptom is usually difficulty in walking. The balance and movement problems gradually worsen and slowly spread to the arms and then the trunk. Foot deformities such as clubfoot (Read about "Clubfoot"), flexion (involuntary bending) of the toes, hammer toes, or foot inversion (turning in) may be early signs. Rapid, rhythmic, involuntary movements of the eyeball are common. (Read about "The Eye") Most people with Friedreich's ataxia develop scoliosis (Read about scoliosis in "Curvature of the Spine") which, if severe, may impair breathing. Other symptoms include chest pain, shortness of breath, and heart palpitations. MDA says most FA patients develop heart disease. (Read about "Coronary Heart Disease") There are no known cures.
According to NINDS, currently there is no cure for peripheral nerve diseases. Treatment options focus on symptomatic relief and medications to block pain.
